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Synfacts 2008(4): 0338-0338  
DOI: 10.1055/s-2008-1042893
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Abyssenine A

Contributor(s): Philip Kocienski, Arndt W. Schmidt
M. Tuomi, F. Couty, G. Evano*
Université de Versailles Saint Quentin en Yvelines, France
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Publication History

Publication Date:
19 March 2008 (online)

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Significance

The first total synthesis of the cyclo­peptide alkaloid abyssenine A is reported. A copper(I)-catalyzed coupling reaction was employed for the ring closure of the 15-membered macro­cycle and for the installation of key functionalities at the aromatic ring.