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Neuropediatrics 1994; 25(3): 154-157
DOI: 10.1055/s-2008-1073014
Short communication

© Georg Thieme Verlag KG Stuttgart · New York

Cerebral Proton Magnetic Resonance Spectroscopic Imaging in a Neonate with Tuberous Sclerosis

F.  Groenendaal1 , Linda C. Meiners3 , R.  Gooskens2 , Linda S. de Vries1
  • 1Department of Neonatology, Wilhelmina Children's Hospital, Utrecht, The Netherlands
  • 2Department of Paediatric Neurology, Wilhelmina Children's Hospital, Utrecht, The Netherlands
  • 3Department of Radiodiagnosis, Utrecht University Hospital, Utrecht, The Netherlands
Further Information

Publication History

Publication Date:
19 March 2008 (online)

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Abstract

On the basis of detection of cardiac tumours and an intracerebral subependymal mass, the diagnosis of tuberous sclerosis was made in a fullterm neonate. To evaluate cerebral metabolism cerebral mass proton magnetic resonance spectroscopic imaging (1H-MRSI) was performed. A local decrease in N-acetyl-aspartate (NAA), and an increase in choline signals were found. Lactate could neither be demonstrated in the subependymal nodule, nor in the surrounding tissue, thereby rendering the possibility of a high-grade malignant tumour less likely. No major changes were found at 3 and 6 months of age. The present study demonstrates, that 1H-MRSI may be helpful in metabolic evaluation of cerebral masses in patients with tuberous sclerosis.

Abbreviations

Cho: choline
Cr: creatine and phosphocreatine
IR: inversion recovery
1H-MRS: proton magnetic resonance spectroscopy
1H-MRSI: proton magnetic resonance spectroscopic imaging
MRI: magnetic resonance imaging
NAA: N-acetyl-aspartate
ppm: parts per million
PRESS: point-resolved spectroscopy
SE: spin echo
TE: time to echo
TR: time to repeat

Key words

Tuberous sclerosis - Proton magnetic resonance spectroscopic imaging - Subependymal nodule - Hamartoma

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