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Synfacts 2008(8): 0869-0869  
DOI: 10.1055/s-2008-1078514
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Cu-Catalyzed Coupling of Alkynes with Tertiary Amines to Propargyl Amines

Contributor(s): Paul Knochel, Andrei Gavryushin
M. Niu, Z. Yin, H. Fu*, Y. Jiang, Y. Zhao
Tsinghua University, Beijing, Zhengzhou University and Tsingua University, Shenzhen, P. R. of China
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Publication History

Publication Date:
23 July 2008 (online)

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Significance

This is a simple and convenient method for coupling tertiary aliphatic amines with terminal acetylenes into the corresponding propargyl amines, which are useful intermediates in the modern organic synthesis and interesting molecules for biological studies. The reaction is performed selectively on the methyl group of tertiary amines according to a very simple procedure. The reaction represents also a promising approach to design new synthetic methods, basing on C-H activation.