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Synfacts 2008(8): 0791-0791
DOI: 10.1055/s-2008-1078528
DOI: 10.1055/s-2008-1078528
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Formal Synthesis of Neopeltolide
V. V. Vintonyak, M. E. Maier*
Universität Tübingen, Germany
Further Information
Publication History
Publication Date:
23 July 2008 (online)
Significance
Neopeltolide, a marine macrolide isolated from the sponge related to genus Daedalopelta sollas, inhibits the proliferation of adenocarcinoma, ovarian sarcoma and murine leukemia. The Prins cyclization to form the pyran ring in I features as the key step.