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DOI: 10.1055/s-2008-1081488
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Obesity and Type 2 Diabetes are Associated with an Increased Risk of Developing Cancer and a Worse Prognosis; Epidemiological and Mechanistic Evidence
Publication History
received 30.04.2008
accepted 22.05.2008
Publication Date:
05 September 2008 (online)
Abstract
Both obesity and Type 2 diabetes are independently associated with an increased risk of developing cancer and an increased mortality. The etiology is yet to be determined but insulin resistance and hyperinsulinemia maybe important factors. Hyperglycemia, hyperlipidemia and inflammatory cytokines in addition to the insulin-like growth factors are also possible factors involved in the process.
Key words
diabetes - obesity - cancer - epidemiology
References
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Type 2 Diabetes Accelerates Normal Mammary Gland Development and Breast Cancer Progression . Abstract #1326-P American Diabetes Association Scientific Sessions June 2008
Correspondence
D. LeRoithMD, PhD
Chief, Division of Endocrinology, Diabetes & Bone Disease
Department of Medicine
One Gustave L. Levy Place
Atran AB4-36
Box 1055
10029-6574 New York
Phone: 212/241 63 06
Fax: 212/241 41 59
Email: derek.leroith@mssm.edu