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Thromb Haemost 2011; 106(05): 772-778
DOI: 10.1160/TH11-05-0296
Theme Issue Article
Schattauer GmbH

Dendritic cells in atherosclerosis: Functions in immune regulation and beyond

Helga D. Manthey
Rudolf-Virchow-Center/ DFG-Research Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany
,
Alma Zernecke
Rudolf-Virchow-Center/ DFG-Research Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany
› Author Affiliations Financial support: This work was supported by the Deutsche Forschungsgemeinschaft (FOR809, ZE 827/1–2; SFB 688 TPA12; ZE 827/4–1).
Further Information

Publication History

Received: 03 May 2011

Accepted after minor revision: 02 August 2011

Publication Date:
23 November 2017 (online)

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Summary

Chronic inflammation drives the development of atherosclerosis. Dendritic cells (DCs) are known as central mediators of adaptive immune responses and the development of immunological memory and tolerance. DCs are present in non-diseased arteries, and accumulate within atherosclerotic lesions where they can be localised in close vicinity to T cells. Recent work has revealed important functions of DCs in regulating immune mechanisms in atherogenesis, and vaccination strategies using DCs have been explored for treatment of disease. However, in line with a phenotypical and functional overlap with plaque macrophages vascular DCs were also identified to engulf lipids, thus contributing to lipid burden in the vessel wall and initiation of lesion growth. Furthermore, a function of DCs in regulating cholesterol homeostasis has been revealed. Finally, phenotypically distinct plasmacytoid dendritic cells (pDCs) have been identified within atherosclerotic lesions. This review will dissect the multifaceted contribution of DCs and pDCs to the initiation and progression of atherosclerosis and the experimental approaches utilising DCs in therapeutic vaccination strategies.

Keywords

Atherosclerosis - inflammation - dendritic cells
 

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