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Thromb Haemost 2011; 106(05): 839-848
DOI: 10.1160/TH11-07-0501
Theme Issue Article
Schattauer GmbH

Neutrophilic granulocytes – promiscuous accelerators of atherosclerosis

Maik Drechsler
1   Institute for Cardiovascular Prevention, Ludwig-Maximilians University, Munich, Germany
,
Yvonne Döring
1   Institute for Cardiovascular Prevention, Ludwig-Maximilians University, Munich, Germany
,
Remco T. A. Megens
1   Institute for Cardiovascular Prevention, Ludwig-Maximilians University, Munich, Germany
,
Oliver Soehnlein
1   Institute for Cardiovascular Prevention, Ludwig-Maximilians University, Munich, Germany
› Author Affiliations
Further Information

Publication History

Received: 20 July 2011

Accepted after minor revision 28 September 2011

Publication Date:
23 November 2017 (online)

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Summary

Neutrophils, as part of the innate immune system, are classically described to be main actors during the onset of inflammation enforcing rapid neutralisation and clearance of pathogens. Besides their wellstudied role in acute inflammatory processes, recent advances strongly indicate a so far underappreciated importance of neutrophils in initiation and development of atherosclerosis. This review focuses on current findings on the role of neutrophils in atherosclerosis. As pro-inflammatory mechanisms of neutrophils have primarily been studied in the microvascular environment; we here aim at translating these into the context of macrovascular inflammation in atherosclerosis. Since much of the pro-inflammatory activities of neutrophils stem from instructing neighbouring cell types, we highlight the promiscuous interplay between neutrophils and platelets, monocytes, T lymphocytes, and dendritic cells and its possible relevance to atherosclerosis.

Keywords

Atherosclerosis - neutrophil - inflammation - recruitment
 

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