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Hamostaseologie 2012; 32(02): 127-131
DOI: 10.5482/ha-1164
Review
Schattauer GmbH

Clinical significance of circulating microparticles for venous thrombo - embolism in cancer patients

Die klinische Relevanz zirkulierender Mikropartikel für venöse Thromboembolie bei Krebspatienten
J. Thaler
1   Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Comprehensive Cancer Center Vienna, Medical University of Vienna – Vienna General Hospital, Vienna, Austria
,
C. Ay
1   Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Comprehensive Cancer Center Vienna, Medical University of Vienna – Vienna General Hospital, Vienna, Austria
,
I. Pabinger
1   Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Comprehensive Cancer Center Vienna, Medical University of Vienna – Vienna General Hospital, Vienna, Austria
› Author Affiliations
Further Information

Publication History

received: 16 June 2011

accepted: 20 June 2011

Publication Date:
28 December 2017 (online)

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Summary

Cancer patients have a four-to seven-fold increased risk to develop a venous thromboembolic event. Accumulating evidence from experimental and clinical studies indicates that microparticles (MPs), small procoagulant membrane vesicles that are defined by size and a negatively charged phosphatidylserine rich surface, play an important role in the pathogenesis of cancer-related venous thromboembolism (VTE). However, the clinical significance of MPs as a predictive biomarker for VTE in cancer patients has not been fully elucidated yet. This might be due to unresolved methodological problems and a lack of data from large prospective clinical studies that investigate the role of MPs in cancer-related VTE.

It is the aim of this review to give an overview on the most important characteristics of MPs and studies dealing with the role of MPs in cancer-related VTE. Also recent progresses, unresolved problems and future perspectives in this research field will be discussed. In the conclusion we will assess the clinical significance of MPs in cancer-related VTE.

Zusammenfassung

Krebspatienten weisen ein vier-bis siebenfach erhöhtes Risiko auf, eine venöse Thromboembolie (VTE) zu entwickeln. Daten klinischer und experimenteller Studien deuten darauf hin, dass Mikropartikel (MPs), kleine negativ geladene und Phosphatidylserinreiche Membranvesikel, eine wichtige Rolle in der Pathogenese der tumorassoziierten Thrombose spielen. Allerdings ist die klinische Bedeutung von MPs als prädiktiver Biomarker für das Auftreten von VTE bei Krebspatienten noch nicht völlig geklärt. Dies liegt wahrscheinlich an ungelösten methodischen Problemen und einem Mangel an Daten von großen prospektiven Studien, die die Rolle von MPs in der Entstehung der tumor-assoziierten Thrombose untersuchen.

Es ist das Ziel dieser Übersichtsarbeit die wichtigsten Charakteristika von MPs zu beschreiben und von neuen Studien zu berichten. Auch jüngste Fortschritte, ungelöste Probleme und Zukunftsaussichten aus diesem Forschungsgebiet werden besprochen. In der Schlussfolgerung werden wir die klinische Signifikanz von Mikropartikeln in der tumor-assoziierten Thrombose beurteilen.

Keywords

Microparticles - cancer - venous thromboembolism - tissue factor

Schlüsselwörter

Mikropartikel - Krebserkrankungen - venöse Thromboembolie - Tissue Faktor
 

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