TY - JOUR AU - Ahmadian, Elham; Dizaj, Solmaz Maleki; Eftekhari, Aziz; Dalir, Elaheh; Vahedi, Parviz; Hasanzadeh, Amir; Samiei, Mohammad TI - The Potential Applications of Hyaluronic Acid Hydrogels in Biomedicine SN - 2194-9379 SN - 2194-9387 PY - 2020 JO - Drug Res (Stuttg) JF - Drug Research LA - EN VL - 70 IS - 01 SP - 6 EP - 11 ET - 2019/09/25 DA - 2020/01/03 KW - regenerative medicine KW - drug delivery KW - biopharmaceuticals AB - Hyaluronic acid (HA) is widely used in the biomedicine due to its biocompatibility, biodegradability, and nontoxic properties. It is crucial for cell signaling role during morphogenesis, inflammation, and wound repair. After hydrogel formation, HA easily is converted to elastic sheets in order to use in preclinical and clinical applications. In addition, HA-derived hydrogels are easily used as vectors for cell and medication in tissue repairing and regenerative medicine. Moreover, in comparison with other polymers, HA -based hydrogels play a key role in in cellular behavior, including stem cell differentiation. The current paper reviews both basic concepts and recent advances in the development of HA-based hydrogels for biomedical applications. PB - © Georg Thieme Verlag KG DO - 10.1055/a-0991-7585 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-0991-7585 ER -