TY - JOUR AU - Kongkam, Pradermchai; Orprayoon, Theerapat; Boonmee, Chaloemphon; Sodarat, Passakorn; Seabmuangsai, Orathai; Wachiramatharuch, Chatchawan; Auan-Klin, Yutthaya; Pham, Khanh Cong; Tasneem, Abbas Ali; Kerr, Stephen J.; Romano, Rommel; Jangsirikul, Sureeporn; Ridtitid, Wiriyaporn; Angsuwatcharakon, Phonthep; Ratanachu-ek, Thawee; Rerknimitr, Rungsun TI - ERCP plus endoscopic ultrasound-guided biliary drainage versus percutaneous transhepatic biliary drainage for malignant hilar biliary obstruction: a multicenter observational open-label study SN - 0013-726X SN - 1438-8812 PY - 2020 JO - Endoscopy JF - Endoscopy LA - EN VL - 53 IS - 01 SP - 55 EP - 62 DA - 2020/07/08 ET - 2020/06/08 AB - Background Endoscopic retrograde cholangiopancreatography (ERCP) may not provide complete biliary drainage in patients with Bismuth III/IV malignant hilar biliary obstruction (MHBO). Complete biliary drainage is accomplished by adding percutaneous transhepatic biliary drainage (PTBD). We prospectively compared recurrent biliary obstruction (RBO) rates between combined ERCP and endoscopic ultrasound-guided biliary drainage (EUS-BD) vs. bilateral PTBD. Methods Patients with MHBO undergoing endoscopic procedures (group A) were compared with those undergoing bilateral PTBD (group B). The primary outcome was the 3-month RBO rate. Results 36 patients were recruited into groups A (n = 19) and B (n = 17). Rates of technical and clinical success, and complications of group A vs. B were 84.2 % (16/19) vs. 100 % (17/17; P = 0.23), 78.9 % (15/19) vs. 76.5 % (13/17; P > 0.99), and 26.3 % (5/19) vs. 35.3 % (6/17; P = 0.56), respectively. Within 3 and 6 months, RBO rates of group A vs. group B were 26.7 % (4/15) vs. 88.2 % (15/17; P  = 0.001) and 22.2 % (2/9) vs. 100 % (9/9; P = 0.002), respectively. At 3 months, median number of biliary reinterventions in group A was significantly lower than in group B (0 [interquartile range] 0–1 vs. 1 [1–2.5]), respectively (P < 0.001). Median time to development of RBO was longer in group A than in group B (92 [56–217] vs. 40 [13.5–57.8] days, respectively; P  =  0.06).Conclusions Combined ERCP and EUS procedures provided significantly lower RBO rates at 3 and 6 months vs. bilateral PTBD, with similar complication rates and no significant mortality difference. PB - Georg Thieme Verlag KG DO - 10.1055/a-1195-8197 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1195-8197 ER -