TY - JOUR AU - Spurlin, Racheal M.; Harris, Amber L.; Pratt, Cameron J.; Jui, Nathan T. TI - Synthesis of Spirocyclic Piperidines by Radical Hydroarylation SN - 0936-5214 SN - 1437-2096 PY - 2020 JO - Synlett JF - Synlett LA - EN VL - 32 IS - 02 SP - 211 EP - 214 DA - 2020/12/18 ET - 2020/11/19 KW - photoredox catalysis KW - spirocyclization KW - piperidines KW - ­hydroarylation KW - radicals AB - Reported here are conditions for the construction of spirocyclic piperidines from linear aryl halide precursors. These conditions employ a strongly reducing organic photoredox catalyst in combination with a trialkylamine reductant to achieve formation of aryl radical species. Regioselective cyclization followed by hydrogen-atom transfer affords a range of complex spiropiperidines. This system operates efficiently under mild conditions without the need for toxic reagents or precious metals. PB - Georg Thieme Verlag KG DO - 10.1055/a-1315-1014 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1315-1014 ER -