TY - JOUR AU - Kaur, Parmjit Heer; Davies, Paul W. TI - Gold-Catalysed Cycloisomerisation of Ynamides To Access 2,2-Disubstituted Tetrahydrothiophene Motifs SN - 0936-5214 SN - 1437-2096 PY - 2021 JO - Synlett JF - Synlett LA - EN VL - 32 IS - 09 SP - 897 EP - 900 DA - 2021/04/07 ET - 2021/03/13 KW - gold KW - ynamides KW - isomerization KW - ylides KW - regioselectivity KW - thiophenecarboxamides AB - Ynamides bearing a tethered allyl sulfoxide undergo a gold-catalysed cycloisomerisation to afford tetrahydrothiophene-2-carboxamides and their benzo-fused analogues. The reactions are initiated by a formal 7-endo-dig cyclisation and accommodate a range of different substituents. The use of N-allyl ynamides provided a route into novel spirocyclic ε-lactam structures. PB - Georg Thieme Verlag KG DO - 10.1055/a-1434-4273 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1434-4273 ER -