TY - JOUR AU - Zhou, Qiansujia; Yin, Si-Yong; Zheng, Dong-Song; Zhang, Wen-Wen; Zhang, Su-Zhen; Gu, Qing; You, Shu-Li TI - Enantioselective Synthesis of Axially Chiral 1-Arylisoquinolines by Iridium(I)-Catalyzed Hydroarylation of Alkynes SN - 0936-5214 SN - 1437-2096 PY - 2023 JO - Synlett JF - Synlett LA - EN VL - 34 IS - 12 SP - 1442 EP - 1446 DA - 2023/02/22 ET - 2023/01/29 KW - alkynes KW - isoquinolines KW - axial chirality KW - C–H functionalization KW - iridium catalysis KW - asymmetric synthesis AB - Ir(I)-catalyzed atroposelective hydroarylation of alkynes with 1-arylisoquinolines through C–H functionalization was realized. In the presence of 5 mol% of [Ir(cod)Cl]2 and 10 mol% of QUINOX-P, a wide range of axially chiral alkenylated biaryls were obtained in up to 98% yield and 97% ee. Notably, only one equivalent of the alkyne was required to guarantee a high efficiency of this C–H functionalization process. This reaction exhibits excellent functional-group tolerance under mild conditions. PB - Georg Thieme Verlag KG DO - 10.1055/a-2021-9514 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2021-9514 ER -