Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation. - Du,XL.; Edelstein,D.; Rossetti,L.; Fantus,IG.; Goldberg,H.; Ziyadeh,F.; Wu,J.; Brownlee,M. (Proc Natl Acad Sci USA, 2000)