Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. - Kumar,A.; Roberts,D.; Wood,KE.; Light,B.; Parrillo,JE.; Sharma,S.; Suppes,R.; Feinstein,D.; Zanotti,S.; Taiberg,L.; Gurka,D.; Kumar,A.; et al. (Crit Care Med, 2006)