The PREMIER study. A multicenter, randomized, double blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. - Breedveld,F.; Weisman,M.; Kavanaugh,A. (Arthritis Rheum, 2006)