Discovery and optimization of a novel spiropyrrolidine inhibitor of β-secretase (BACE1) through fragment-based drug design - Efremov, I V; Vajdos, F F; Borzilleri, K A; Capetta, S; Chen, H; Dorff, P H; Dutra, J K; Goldstein, S W; Mansour, M; McColl, A; Noell, S; Oborski, C E; OʼConnell, T N; OʼSullivan, T J; Pandit, J; Wang, H; Wei, B Q; Withka, J M (J Med Chem, 2012)