TY - JOUR AU - Bates, Sara V.; Lakshmanan, Ashwini; Green, Adam L.; Terry, Jefferson; Badalian-Very, Gayane; Rollins, Barrett J.; Fleck, Patricia; Aslam, Muhammad; Degar, Barbara A. TI - BRAF V600E-Positive Multisite Langerhans Cell Histiocytosis in a Preterm Neonate SN - 2157-6998 SN - 2157-7005 PY - 2013 JO - AJP Rep JF - American Journal of Perinatology Reports LA - EN VL - 03 IS - 02 SP - 063 EP - 066 ET - 2013/03/18 DA - 2013/10/18 KW - Langerhans cell histiocytosis KW - BRAF V600E KW - preterm neonate KW - multiorgan KW - multisite KW - hemorrhagic pustules AB - Hemorrhagic pustules with a “blueberry muffin” appearance accompanied by respiratory failure in a neonate present a challenging differential diagnosis that includes infections and neoplasms. We present a case of multiorgan, multisite Langerhans cell histiocytosis (LCH), positive for the oncogenic BRAF V600E mutation, in a preterm neonate. Infants with LCH pose a diagnostic challenge due to their heterogeneous presentations. This case is unusual in that the newborn presented with severe multiorgan involvement. Due to the rare incidence, wide spectrum of clinical manifestations, and high mortality rate, clinicians must maintain a high index of suspicion for LCH. PB - Thieme Medical Publishers DO - 10.1055/s-0033-1338168 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0033-1338168 ER -