TY - JOUR AU - Danelius, Emma; Brath, Ulrika; Erdélyi, Máté TI - Insight into β-Hairpin Stability: Interstrand Hydrogen Bonding SN - 0936-5214 SN - 1437-2096 PY - 2013 JO - Synlett JF - Synlett LA - EN VL - 24 IS - 18 SP - 2407 EP - 2410 ET - 2013/08/28 DA - 2013/10/25 KW - peptides KW - spectroscopy KW - macrocycles KW - β-hairpin KW - conformation AB - For evaluation of the role of interstrand hydrogen bonding for β-hairpin stability, two cyclic peptides differing only in side chain hydroxy-to-methyl substitution were designed and synthesized on solid phase following the Fmoc–t-Bu–Trt protection strategy. Subsequent to cyclization in solution, combined computational and experimental ensemble analysis revealed higher conformational stability of the peptide capable of interstrand hydrogen bonding. PB - © Georg Thieme Verlag DO - 10.1055/s-0033-1339670 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0033-1339670 ER -