(untitled) - van den Berg, R J. B. H. N; Wennekes, T; Ghisaidoobe, A; Donker-Koopman, W E; Strijland, A; Boot, R G; van der Marel, G A; Aerts, J M. F. G; Overkleeft, H S (ACS Med. Chem. Lett., 2011)
The results obtained for the O-alkylated derivatives can be explained, in part, by the fact that the C2-hydroxyl group of the DNJ core is important for glycosylceramide synthase inhibition, as recently demonstrated; see: