TY - JOUR AU - Wu, Hua; He, Yu-Ping; Shi, Feng TI - Recent Advances in Chiral Phosphoric Acid Catalyzed Asymmetric Reactions for the Synthesis of Enantiopure Indole Derivatives SN - 0039-7881 SN - 1437-210X PY - 2015 JO - Synthesis JF - Synthesis LA - EN VL - 47 IS - 14 SP - 1990 EP - 2016 ET - 2015/06/24 DA - 2015/07/06 KW - chiral indole derivatives KW - chiral phosphoric acids KW - asymmetric reactions KW - addition reactions KW - cycloaddition reactions KW - cascade reactions AB - Chiral indole derivatives are an intriguing class of heterocyclic compounds; their structural motifs are frequently found in natural products and synthetic compounds with significant bioactivity. Among many synthetic transformations leading to the production of enantiopure indole derivatives, chiral phosphoric acid catalyzed reactions are the most attractive methodologies, since these reactions can directly afford enantiomerically pure indole derivatives from readily accessible starting materials under mild conditions. In this review, the most recent achievements in this research area have been gathered and classified according to different reaction types for the synthesis of enantioenriched indole derivatives under the catalysis of chiral phosphoric acids.1 Introduction2 Chiral Phosphoric Acid Catalyzed Asymmetric Addition Reactions2.1 1,2-Addition Reactions2.2 1,4-Addition Reactions3 Chiral Phosphoric Acid Catalyzed Asymmetric Cycloaddition Reactions3.1 [3+2] Reactions3.2 [4+2] Reactions3.3 [3+3] Reactions4 Chiral Phosphoric Acid Catalyzed Asymmetric Cascade Reactions4.1 Cascade Reactions4.2 Transition-Metal-Cocatalyzed Cascade Reactions4.3 Other Organocatalyst-Cocatalyzed Cascade Reactions5 Other Reactions Catalyzed by Chiral Phosphoric Acids5.1 Aza-Claisen Rearrangement5.2 Kinetic Resolution5.3 Fischer Indolization6 Conclusions and Perspective PB - © Georg Thieme Verlag DO - 10.1055/s-0034-1378837 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0034-1378837 ER -