TY - JOUR AU - Demmer, Charles S.; Evano, Gwilherm TI - A Simple Entry to Yne-amides from Yne-oxazolidinones SN - 0936-5214 SN - 1437-2096 PY - 2016 JO - Synlett JF - Synlett LA - EN VL - 27 IS - 12 SP - 1873 EP - 1877 ET - 2016/04/05 DA - 2016/07/08 KW - ynamides KW - yne-oxazolidinones KW - organolithium KW - ring opening KW - alkynes AB - A convenient entry to yne-amides, useful building blocks for chemical synthesis whose synthesis can be rather difficult – especially in the acyclic series – is reported. They were found to be readily obtained by a simple ring opening of the corresponding, readily available yne-oxazolidinones with organolithium reagents. Surprisingly, no competitive carbolithiation of the highly reactive nitrogen-substituted alkyne or propargylic lithiation were observed, this method therefore providing a useful entry to yne-amides which can be obtained in fair to good yields. PB - © Georg Thieme Verlag DO - 10.1055/s-0035-1561976 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0035-1561976 ER -