TY - JOUR AU - Suo, Jian-Feng; Zhao, Xue-Mei; Zhang, Kai-Xin; Zhou, Sheng-Li; Niu, Jun-Long; Song, Mao-Ping TI - Cobalt-Catalyzed Perfluoroalkylation of Quinoline Amides at the C5 Position SN - 0039-7881 SN - 1437-210X PY - 2017 JO - Synthesis JF - Synthesis LA - EN VL - 49 IS - 17 SP - 3916 EP - 3924 ET - 2017/03/29 DA - 2017/08/21 KW - cobalt KW - 8-aminoquinolines KW - catalysis KW - fluorine KW - perfluoroalkyl iodides KW - perfluoroalkylation AB - An efficient protocol has been developed for the cobalt-catalyzed perfluoroalkylation of 8-aminoquinoline scaffolds. In the presence of 5 mol% of Co(acac)3 catalyst, the desired products were obtained with exclusive substitution at the C5 position of the quinoline ring after 4 hours. The reaction shows high efficiency and good tolerance for a broad range of functional groups, affording the corresponding products in moderate to good yields. PB - © Georg Thieme Verlag DO - 10.1055/s-0036-1588160 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0036-1588160 ER -