TY - JOUR AU - Matsumoto, Nobuyuki; Nakazaki, Atsuo; Nishikawa, Toshio TI - Concise Synthesis of a Cyclopentane Intermediate Possessing All Nitrogen Functionalities for Pactamycin SN - 0936-5214 SN - 1437-2096 PY - 2017 JO - Synlett JF - Synlett LA - EN VL - 28 IS - 17 SP - 2303 EP - 2306 ET - 2017/07/27 DA - 2017/10/10 KW - natural product synthesis KW - pactamycin KW - aminocyclopentitol KW - oxime–olefin cycloaddition KW - aziridines AB - Pactamycin, a potent antitumor and antimicrobial antibiotic, possesses a densely functionalized cyclopentane core structure. This paper describes the concise synthesis of an advanced intermediate for synthesizing the enantiomer of pactamycin that contains the cyclopentane skeleton bearing all the necessary amino functions with correct stereochemistries. PB - © Georg Thieme Verlag DO - 10.1055/s-0036-1588495 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0036-1588495 ER -