TY - JOUR AU - Ellwart, Mario; Höfner, Georg; Gerwien, Aaron; Wanner, Klaus T.; Knochel, Paul TI - Synthesis and Bioactivity of Novel N-Benzylic and N-Phenethylic Ephedrine Derivatives SN - 0039-7881 SN - 1437-210X PY - 2017 JO - Synthesis JF - Synthesis LA - EN VL - 49 IS - 23 SP - 5159 EP - 5166 ET - 2017/08/23 DA - 2017/11/20 KW - organozinc halides KW - organomagnesium halides KW - iminium ion KW - ephedrine KW - binding assays AB - A range of N-benzylic and N-phenethylic ephedrine derivatives were prepared in a one-pot procedure starting from the two enantiomers of ephedrine using the Potier reagent, and a polyfunctional aryl- or benzylic organozinc halide. The biological activity in indatraline MS Binding Assays addressing hDAT, hNET and hSERT was determined and discussed. PB - © Georg Thieme Verlag DO - 10.1055/s-0036-1588523 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0036-1588523 ER -