TY - JOUR AU - Kaduskar, Rahul D.; Pinto, Andrea; Scaglioni, Leonardo; Musso, Loana; Dallavalle, Sabrina TI - Synthesis of the Tripeptide Antibiotic Resormycin SN - 0039-7881 SN - 1437-210X PY - 2017 JO - Synthesis JF - Synthesis LA - EN VL - 49 IS - 24 SP - 5351 EP - 5356 ET - 2017/08/28 DA - 2017/12/06 KW - Streptomyces KW - antifungal agents KW - tripeptides KW - natural products KW - amino acids KW - total synthesis AB - A short and efficient synthesis of resormycin, a metabolite of Streptomyces platensis MJ953-SF5 with herbicidal and antifungal activity, is described. The key step in our synthetic approach is a late-stage stereospecific dehydration of a β-hydroxy amino acid to install the Z-olefin. Because of the modular nature of the synthesis, access to analogues for biological evaluation is readily available. PB - © Georg Thieme Verlag DO - 10.1055/s-0036-1588553 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0036-1588553 ER -