TY - JOUR AU - Biswas, Promita; Paul, Subhasis; Guin, Joyram TI - Synthesis of 3,3-Dialkylated Oxindoles by Oxidative Radical 1,2-Alkylarylation of α,β-Unsaturated Amides SN - 0936-5214 SN - 1437-2096 PY - 2017 JO - Synlett JF - Synlett LA - EN VL - 28 IS - 11 SP - 1244 EP - 1249 ET - 2017/03/21 DA - 2017/06/20 KW - C–H functionalization KW - radical cascade reactions KW - oxindoles KW - alkyl radicals KW - alkenes AB - 3,3-Dialkylated oxindoles (1,3-dihydro-2H-indol-2-ones), particularly those containing C3 quaternary stereogenic centers, occupy an important place in organic synthesis and drug discovery. The radical 1,2-alkylarylation of activated olefins with alkyl radicals has emerged as the most atom- and step-economical approach to 3,3-dialkylated oxindoles. This article covers important developments in the area of oxidative radical alkylation/cyclization cascade reactions of α,β-unsaturated amides toward the synthesis of alkyl-substituted oxindoles by employing a range of alkyl-radical precursors and various reaction conditions. PB - © Georg Thieme Verlag DO - 10.1055/s-0036-1588754 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0036-1588754 ER -