TY - JOUR AU - Li, Jie; Xiao, Jun-An; Zhao, Shu-Juan; Xiang, Hao-Yue; Yang, Hua TI - Facile Construction of Pyrrolo[1,2-a]indolenine Scaffold via Dia­stereoselective [3+2] Annulation of Donor–Acceptor Cyclopropane with Indolenine SN - 0039-7881 SN - 1437-210X PY - 2017 JO - Synthesis JF - Synthesis LA - EN VL - 49 IS - 18 SP - 4292 EP - 4298 ET - 2017/07/19 DA - 2017/09/05 KW - pyrrolo[1,2-a]indolenine KW - cyclopropane KW - indolenine KW - [3+2] annulation KW - ring opening AB - A novel synthetic protocol for the assembly of pyrrolo[1,2-a]indolenine has been developed through a highly diastereoselective [3+2] annulation of 1,1-cyclopropanediesters with indolenines in the presence of catalytic Yb(OTf)3. This new strategy allows a facile construction of the multicyclic system with the flexible variation on the substituents in high yields (up to 86%) with excellent diastereoselectivities (>20:1 dr) in most cases. PB - © Georg Thieme Verlag DO - 10.1055/s-0036-1588876 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0036-1588876 ER -