TY - JOUR AU - Wilson, Kirsty L.; Murray, Jane; Jamieson, Craig; Watson, Allan J. B. TI - Cyrene as a Bio-Based Solvent for the Suzuki–Miyaura Cross-Coupling SN - 0936-5214 SN - 1437-2096 PY - 2018 JO - Synlett JF - Synlett LA - EN VL - 29 IS - 05 SP - 650 EP - 654 ET - 2017/12/11 DA - 2018/03/02 KW - boron KW - cross-coupling KW - green chemistry KW - palladium KW - solvents AB - The Suzuki–Miyaura (SM) cross-coupling is the most broadly utilized Pd-catalyzed C–C bond-forming reaction in the chemical industry. A large proportion of SM couplings employ dipolar aprotic solvents; however, current sustainability initiatives and increasingly stringent regulations advocate the use of alternatives that exhibit more desirable properties. Here we describe the scope and utility of the bio-derived solvent Cyrene™ in SM cross-couplings and evaluate its suitability as a reaction medium for this benchmark transformation from discovery to gram scale. PB - © Georg Thieme Verlag DO - 10.1055/s-0036-1589143 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0036-1589143 ER -