TY - JOUR AU - Narayanam, Maruthi Kumar; Ma, Gaoyuan; Champagne, Pier Alexandre; Houk, Kendall N.; Murphy, Jennifer M. TI - Nucleophilic 18F-Fluorination of Anilines via N-Arylsydnone Intermediates SN - 0936-5214 SN - 1437-2096 PY - 2018 JO - Synlett JF - Synlett LA - EN VL - 29 IS - 09 SP - 1131 EP - 1135 ET - 2018/02/26 DA - 2018/05/18 KW - fluorine-18 KW - sydnone KW - bioorthogonal chemistry KW - fluoroarene KW - peptide labeling AB - Preparation of [18F]fluoroarenes with nucleophilic [18F]fluoride for positron emission tomography (PET) molecular imaging ­research is a challenging chemical endeavor. Advances in radiofluorination have soared in the last decade, broadening the availability of potential [18F]fluoroarenes. In this Synpacts article, we highlight the ­recent development from our laboratory of a practical radiofluorination of anilines via N-arylsydnone intermediates to afford [18F]fluoroarenes. Further, we emphasize the utility of this methodology towards peptide labeling applications by preparing an 18F-labeled neuropeptide.1 Introduction2 Nucleophilic Radiofluorination of N-Arylsydnones3 Substrate Scope and Applications4 Conclusion PB - © Georg Thieme Verlag DO - 10.1055/s-0036-1591948 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0036-1591948 ER -