TY - JOUR AU - Makarem, Ata; Konrad, Moritz; Liolios, Christos; Kopka, Klaus TI - A Convenient Synthesis for HBED-CC-tris(tert-butyl ester) SN - 0936-5214 SN - 1437-2096 PY - 2018 JO - Synlett JF - Synlett LA - EN VL - 29 IS - 09 SP - 1239 EP - 1243 ET - 2018/03/07 DA - 2018/05/18 KW - HBED-CC KW - bifunctional chelator KW - hexadentate ligand KW - synthesis KW - radiotracer AB - HBED-CC is a bifunctional complexing agent that, at ambient temperature, tightly chelates the trivalent radiometal 68Ga (T1/2 = 68 min). This complexing agent has attracted a lot of interest in tumor imaging applications. Depending on the chemical structure, different HBED-CC variants may be employed as radiolabeling precursor for the synthesis of desired radiopharmaceuticals. In this context, HBED-CC-tris(tert-butyl ester) is the only known monovalent variant of HBED-CC which is used for the synthesis of non-symmetric HBED-CC-based radiopharmaceuticals. Commercial HBED-CC-tris(tert-butyl ester) is very ­expensive, with limited availability. Nevertheless, no synthetic procedure for this useful product has been reported to date. This work introduces a convenient and comparatively cost-efficient method for the preparation of HBED-CC-tris(tert-butyl ester). PB - © Georg Thieme Verlag DO - 10.1055/s-0036-1591950 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0036-1591950 ER -