TY - JOUR AU - Murarka, Sandip; Antonchick, Andrey P. TI - Metal-Catalyzed Oxidative Coupling of Ketones and Ketone Enolates SN - 0039-7881 SN - 1437-210X PY - 2018 JO - Synthesis JF - Synthesis LA - EN VL - 50 IS - 11 SP - 2150 EP - 2162 ET - 2018/05/03 DA - 2018/05/22 KW - ketone KW - oxidative coupling KW - C–H functionalization KW - cross-dehydrogenative coupling KW - radical AB - Recent years have witnessed a significant advancement in the field of radical oxidative coupling of ketones towards the synthesis of highly useful synthetic building blocks, such as 1,4-dicarbonyl compounds, and biologically important heterocyclic and carbocyclic compounds. Besides oxidative homo- and cross-coupling of enolates, other powerful methods involving direct C(sp3)–H functionalizations of ketones­ have emerged towards the synthesis of 1,4-dicarbonyl compounds. Moreover, direct α-C–H functionalization of ketones has also allowed an efficient access to carbocycles and heterocycles. This review summarizes all these developments made since 2008 in the field of metal-catalyzed/promoted radical-mediated functionalization of ketones at the α-position.1 Introduction2 Synthesis of 1,4-Dicarbonyl Compounds3 Synthesis of Heterocyclic Scaffolds4 Synthesis of Carbocyclic Scaffolds5 Conclusion PB - © Georg Thieme Verlag DO - 10.1055/s-0037-1609715 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0037-1609715 ER -