TY - JOUR AU - Vandavasi, Jaya Kishore; Newman, Stephen G. TI - A High-Throughput Approach to Discovery: Heck-Type Reactivity with Aldehydes SN - 0936-5214 SN - 1437-2096 PY - 2018 JO - Synlett JF - Synlett LA - EN VL - 29 IS - 16 SP - 2081 EP - 2086 ET - 2018/06/12 DA - 2018/09/21 KW - Heck reaction KW - cross-coupling KW - nickel KW - high-throughput ­experimentation KW - reaction discovery AB - The classical Heck reaction is among the most powerful methods available for the construction of C–C bonds. Modification of this transformation to utilize diverse organohalide coupling partners has resulted in new reactions such as the silyl-Heck, aza-Heck, and boryl-Heck reactions. In contrast, modification of the olefin coupling partner is rare. For instance, use of the π-bond of an aldehyde instead of an alkene would provide ketones via a carbonyl-Heck process. This seemingly minor manipulation of the Heck reaction has proven surprisingly difficult to realize in practice. Through the use of high-throughput ­experimentation techniques, an efficient catalyst system for this transformation was identified, enabling the intermolecular coupling of ­organotriflates and aldehydes to synthesize diverse ketones. PB - © Georg Thieme Verlag DO - 10.1055/s-0037-1610161 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0037-1610161 ER -