TY - JOUR AU - Balalaie, Saeed; Ghoroghaghaei, Hadiseh Bakhshaei; Alavijeh, Nahid S.; Darvish, Fatemeh; Rominger, Frank; Bijanzadeh, Hamid Reza TI - Synthesis of Fully Functionalized 3-Bromoazaspiro[4.5]trienones through Ugi Four-Component Reaction (Ugi-4CR) followed by ipso-Bromocyclization SN - 2509-9396 PY - 2018 JO - SynOpen JF - SynOpen LA - EN VL - 02 IS - 03 SP - 0222 EP - 0228 DA - 2018/07/19 KW - alkynes KW - spiro compounds KW - cyclization KW - radical reaction KW - ring closure AB - Biologically attractive azaspiro[4.5]trienones have been prepared via Ugi four-component reaction (Ugi-4CR) followed by bromine-mediated ipso-cyclization. This allows a straightforward synthetic route to a diverse collection of fully functionalized 3-bromoaza­spiro[4,5]trienones in moderate to good yields that can be used as templates for further modifications. PB - Georg Thieme Verlag DO - 10.1055/s-0037-1610205 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0037-1610205 ER -