TY - JOUR AU - Sonawane, Amol D.; Shaikh, Yunnus B.; Garud, Dinesh R.; Koketsu, Mamoru TI - Synthesis of Isoquinoline-Fused Quinazolinones through Ag(I)-Catalyzed Cascade Annulation of 2-Aminobenzamides and 2-Alkynylbenzaldehydes SN - 0039-7881 SN - 1437-210X PY - 2019 JO - Synthesis JF - Synthesis LA - EN VL - 51 IS - 02 SP - 500 EP - 507 ET - 2018/09/21 DA - 2019/01/03 KW - isoquinoline KW - quinazolinone KW - regioisomer KW - silver catalyst KW - cascade annulation AB - A new route for the expedient synthesis of a specific regioisomer of isoquinoline-fused quinazolinones is reported. Silver(I)-catalyzed cascade cyclization of 2-aminobenzamides and 2-alkynylbenzaldehydes followed by in situ oxidation gives 12-butyl- or 12-aryl-6H-isoquinolino[2,1-a]quinazolin-6-ones in 69–91% yields. The structure of the isoquinoline-fused quinazolinone was confirmed by X-ray crystallography analysis. PB - © Georg Thieme Verlag DO - 10.1055/s-0037-1610910 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0037-1610910 ER -