TY - JOUR AU - James, Reuben R.; Herlugson, Sharon; Varjosaari, Sami E.; Skrypai, Vladislav; Shakeel, Zainab; Gilbert, Thomas M.; Adler, Marc J. TI - One-Pot Reductive Acetylation of Aldehydes using 1-Hydrosilatrane in Acetic Acid SN - 2509-9396 PY - 2019 JO - SynOpen JF - SynOpen LA - EN VL - 03 IS - 01 SP - 1 EP - 3 DA - 2019/01/03 KW - esterification KW - reduction KW - silatrane KW - one-pot synthesis AB - A one-pot, direct reductive acetylation of aldehydes was achieved under mild conditions using 1-hydrosilatrane as a safe and easily accessible catalyst. Described herein is a facile synthesis that produces acylated primary alcohols that can serve as valuable building blocks for organic synthesis. The method has good functional group tolerance and works for a range of aryl aldehydes, with the notable exception of electron-rich arenes. A library of esters was isolated by flash chromatography in yields as high as 92%. PB - Georg Thieme Verlag DO - 10.1055/s-0037-1611697 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0037-1611697 ER -