TY - JOUR AU - Andrade, Valquiria P.; Mittersteiner, Mateus; Bonacorso, Helio G.; Frizzo, Clarissa P.; Martins, Marcos A. P.; Zanatta, Nilo TI - Regioselective Synthesis of 5-(Trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidines from β-Enamino Diketones SN - 0039-7881 SN - 1437-210X PY - 2019 JO - Synthesis JF - Synthesis LA - EN VL - 51 IS - 11 SP - 2311 EP - 2317 ET - 2019/03/21 DA - 2019/05/16 KW - β-enamino diketones KW - 1,3-diones KW - triazolopyrimidines KW - aminotriazoles KW - fluorinated heterocycles AB - The use of β-enamino diketones as an easy entry to the regioselective synthesis of [1,2,4]triazolo[1,5-a]pyrimidines is reported. These ketones reacted with 3-amino-1H-1,2,4-triazoles to furnish exclusively 6-substituted 5-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidines in yields of up to 95%. The regioselectivity of the reactions performed was maintained regardless of the substituent in the starting ketone or aminoazole. PB - © Georg Thieme Verlag DO - 10.1055/s-0037-1611765 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0037-1611765 ER -