TY - JOUR AU - Arita, Mao; Yokoyama, Soichi; Asahara, Haruyasu; Nishiwaki, Nagatoshi TI - Facile Synthesis of Onychines SN - 0039-7881 SN - 1437-210X PY - 2019 JO - Synthesis JF - Synthesis LA - EN VL - 51 IS - 09 SP - 2007 EP - 2013 ET - 2019/02/19 DA - 2019/04/15 KW - onychine KW - polysubstituted nicotinates KW - iron(III) chloride KW - ­intramolecular Friedel–Crafts reaction KW - enone AB - The FeCl3-mediated condensation of an α-phenylenamino ester and an enone proceeds efficiently to afford a 2-phenylnicotinate. The subsequent intramolecular Friedel–Crafts reaction yielded an ­onychine framework. Modifications at the 2-, 3-, and 8-positions of the onychine framework were easily achieved by altering the enamino esters­ and enones, which facilitated the discovery of potentially bioactive compounds. PB - © Georg Thieme Verlag DO - 10.1055/s-0037-1612058 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0037-1612058 ER -