TY - JOUR AU - Gupta, Surabhi; Baranwal, Siddharth; Muniyappan, Nalluchamy; Sabiah, Shahulhameed; Kandasamy, Jeyakumar TI - Copper-Catalyzed N-Arylation of Sulfoximines with Arylboronic Acids under Mild Conditions SN - 0039-7881 SN - 1437-210X PY - 2019 JO - Synthesis JF - Synthesis LA - EN VL - 51 IS - 10 SP - 2171 EP - 2182 ET - 2019/02/19 DA - 2019/04/30 KW - arylation KW - boronic acid KW - sulfoximine KW - catalysis KW - copper AB - N-Arylation of sulfoximines with different arylboronic acids, including sterically hindered boronic acids, is achieved using copper(I) iodide and 4-DMAP at room temperature. Moreover, N-arylation of biologically relevant l-methionine sulfoximine is demonstrated for the first time. All these reactions provided the desired products in excellent yields within a short span of time. The optimized reaction conditions are well suited to the task of N-vinylation of sulfoximine with trans-2-phenylvinylboronic acid. PB - © Georg Thieme Verlag DO - 10.1055/s-0037-1612216 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0037-1612216 ER -