Mutation Arg2150His in the factor VIII C1 domain alters the binding of factor VIII to von Wille-brand factor and is responsible for a mild hemophilia phenotype - Jacquemin, MG; Peerlinck, K; Gilles, JGG; Benhida, A; Desqueper, B; Lavend’homme, R; Vermylen, J; Saint-Remy, JMR (Blood, 1998)