TY - JOUR AU - Isakov, Kimberly M. M.; Emerson, John W.; Campbell, Katherine H.; Galerneau, France; Anders, Amber M.; Lee, Yoonjoo K.; Subramanyam, Pritha; Roberts, Andrea E.; Kliman, Harvey J. TI - Estimated Placental Volume and Gestational Age SN - 0735-1631 SN - 1098-8785 PY - 2018 JO - Am J Perinatol JF - American Journal of Perinatology LA - EN VL - 35 IS - 08 SP - 748 EP - 757 ET - 2017/12/27 DA - 2018/06/18 KW - placenta KW - volume KW - ultrasound KW - birth weight AB - Objective The objective of this study was to validate estimated placental volume (EPV) across a range of gestational ages (GAs).Study Design Three hundred sixty-six patients from 2009 to 2011 received ultrasound scans between 11 + 0 and 38 + 6 weeks GA to assess EPV. An EPV versus GA best fit curve was generated and compared with published normative curves of EPV versus GA in a different population. A subanalysis was performed to explore the relationship between EPV and birth weight (BW).Results Analysis of EPV versus GA revealed a parabolic curve with the following best fit equation: EPV = (0.372 GA − 0.00364 GA2)3. EPV was weakly correlated with BW, and patients with an EPV in the bottom 50th percentile had 2.42 times the odds of having a newborn with a BW in the bottom 50th percentile (95% confidence interval: 1.27–4.68). Microscopic evaluation of two placentas corresponding to the smallest EPV outliers revealed significant placental pathology.Conclusion Placental volume increases throughout gestation and follows a predictable parabolic curve, in agreement with the existing literature. Further validation is required, but EPV may have the potential for clinical utility as a screening tool in a variety of settings. PB - Thieme Medical Publishers DO - 10.1055/s-0037-1615285 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0037-1615285 ER -