A variant of tissue plasminogen activator (T103N, N117Q, KHRR296-299AAAA) with a decreased plasma clearance rate, is substantially more potent than Activase rt-PA in a rabbit thrombolysis model - Refino, C; Keyt, B; Paoni, N; Badillo, J; Pater, C; Van Peborgh, J; Pena, L; Berleau, L; Nguyen, H; Bennett, W (Thromb Haemost, 1993)
(Abstr 1074)