A patient with von Willebrand‗s disease characterized by a compound heterozygosity for a substitution of Arg854 by Gin in the putative factor-VIII-binding domain of von Willebrand factor (vWF) on one allele and very low levels of mRNA from the second vWF allele - Peerlinck, K; Eikenboom, J CJ; Ploos Van Amstel, H K; Sangtawesin, W; Arnout, J; Reitsma, P H; Vermylen, J; Briët, E (Br J Haematol, 1992)