Depolymerized holothurian glycosaminoglycan (DHG) is an anticoagulant with two different inhibitory activities: One, heparin cofactor II-dependent inhibition and the other, antithrombin III-and heparin cofactor II-independent inhibition of factor X activation by factor IXa-factor Villa complex - Nagase, H; Enjyoji, K; Minamiguchi, K; Kitazato, T K; Kitazato, K; Saito, H; Kato, H (Blood, 1995)