TY - JOUR AU - Harris, Benjamin S.; Hopkins, Maeve K.; Villers, Margaret S.; Weber, Jeremy M.; Pieper, Carl; Grotegut, Chad A.; Swamy, Geeta K.; Hughes, Brenna L.; Heine, R Phillips TI - Efficacy of Non-Beta-lactam Antibiotics for Prevention of Cesarean Delivery Surgical Site Infections SN - 2157-6998 SN - 2157-7005 PY - 2019 JO - AJP Rep JF - American Journal of Perinatology Reports LA - EN VL - 09 IS - 02 SP - e167 EP - e171 DA - 2019/04/30 KW - antibiotics KW - penicillin allergy KW - cesarean delivery KW - surgical site infection AB - Objective To examine the association between perioperative Beta (β))-lactam versus non-β-lactam antibiotics and cesarean delivery surgical site infection (SSI).Study Design Retrospective cohort of women undergoing cesarean delivery from January 1 to December 31, 2014. All women undergoing cesarean after 34 weeks with a postpartum visit were included. Prevalence of SSI was compared between women receiving β-lactam versus non-β-lactam antibiotics. Bivariate analyses were performed using Pearson's Chi-square, Fisher's exact, or Wilcoxon's rank-sum tests. Logistic regression models were fit controlling for possible confounders.Results Of the 929 women included, 826 (89%) received β-lactam prophylaxis and 103 (11%) received a non-β-lactam. Among the 893 women who reported a non-type I (low risk) allergy, 819 (92%) received β-lactam prophylaxis. SSI occurred in 7% of women who received β-lactam antibiotics versus 15% of women who received a non-β-lactam (p = 0.004). β-Lactam prophylaxis was associated with lower odds of SSI compared with non-β-lactam antibiotics (odds ratio [OR] = 0.43; 95% confidence interval [CI] = 0.22–0.83; p = 0.01) after controlling for chorioamnionitis in labor, postlabor cesarean, endometritis, tobacco use, and body mass index (BMI).Conclusion β-Lactam perioperative prophylaxis is associated with lower odds of a cesarean delivery surgical site infection compared with non-β-lactam antibiotics. PB - Thieme Medical Publishers DO - 10.1055/s-0039-1685503 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0039-1685503 ER -