TY - JOUR AU - Cortón, Pablo; Novo, Paula; López-Sobrado, Vanesa; García, Marcos D.; Peinador, Carlos; Pazos, Elena TI - Solid-Phase Zincke Reaction for the Synthesis of Peptide-4,4′-bipyridinium Conjugates SN - 0039-7881 SN - 1437-210X PY - 2020 JO - Synthesis JF - Synthesis LA - EN VL - 52 IS - 04 SP - 537 EP - 543 ET - 2019/07/30 DA - 2020/02/03 KW - peptide-based conjugates KW - viologens KW - Zincke reaction KW - solid phase peptide synthesis (SPPS) KW - synthetic methodology AB - We present herein the development of a new synthetic strategy for the conjugation of 4,4′-bipyridinium derivatives into peptide scaffolds. The methodology, based on the development of a solid-phase version of the Zincke reaction between activated pyridinium salts and amines, is able to produce the desired conjugates in a straightforward fashion, with the bipyridinium units attached at the N-terminus of peptides or at Lys side chains of N-terminal acetylated peptides. PB - © Georg Thieme Verlag DO - 10.1055/s-0039-1690016 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0039-1690016 ER -