TY - JOUR AU - Naraoka, Asuka; Naka, Hiroshi TI - Transfer Hydration of Dinitriles to Dicarboxamides SN - 0936-5214 SN - 1437-2096 PY - 2019 JO - Synlett JF - Synlett LA - EN VL - 30 IS - 17 SP - 1977 EP - 1980 ET - 2019/09/24 DA - 2019/10/07 KW - hydration KW - nitriles KW - palladium KW - amides KW - diamides AB - We present a robust method for double transfer hydration of dinitriles to afford diamides. The transfer hydration of 1,n-dinitriles (n = 1–6) proceeds smoothly in the presence of a palladium(II) catalyst with acetamide as a water donor, affording the corresponding diamides in moderate to high yields, without involving significant side reactions such as monohydration or cyclization. The equilibrium was shifted in the forward direction by removing coproduced acetonitrile under reduced pressure. PB - © Georg Thieme Verlag DO - 10.1055/s-0039-1690026 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0039-1690026 ER -