TY - JOUR AU - Chen, Dianpeng; Li, Jianming; Shan, Yingying; Cui, Peiying; Zhao, Yutong; Tian, Laijin; Qiu, Guanyinsheng TI - Halogen-Radical-Promoted Dearomative Aza-Spirocyclization of Alkynylimines: An Efficient Approach to 3-Halo-Spirocyclohexadienones SN - 0039-7881 SN - 1437-210X PY - 2020 JO - Synthesis JF - Synthesis LA - EN VL - 52 IS - 04 SP - 609 EP - 618 ET - 2019/11/13 DA - 2020/02/03 KW - halogen radical KW - dearomative aza-spirocyclization KW - alkynylimine KW - 3-halo-spirocyclohexadienone KW - 5-exo-trig cyclization AB - A novel halogen-radical-promoted dearomative aza-spiro­cyclization of alkynylimines for the synthesis of 3-halo-spirocyclohexadienones is described. In this process, it is believed that a radical addition, 5-exo-trig cyclization, and dearomative aza-spirocyclization are involved. Easily available starting materials, mild conditions, and a wide substrate scope make this approach potentially useful. PB - © Georg Thieme Verlag DO - 10.1055/s-0039-1690746 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0039-1690746 ER -