TY - JOUR AU - Rava, Alessandro; Bruzzone, Matteo; Cottino, Umberto; Enrietti, Emilio; Rossi, Roberto TI - Hip Spacers in Two-Stage Revision for Periprosthetic Joint Infection: A Review of Literature SN - 2282-4324 SN - 2512-9090 PY - 2019 JO - Joints JF - Joints LA - EN VL - 07 IS - 02 SP - 056 EP - 063 ET - 2019/10/11 DA - 2019/12/25 KW - antibiotic KW - hip KW - infection KW - periprosthetic joint infections KW - antibiotic-loaded spacers AB - Infection after total hip arthroplasty (THA) is a devastating complication with significant consequences for patients. In literature, single and two-stage revision, irrigation and debridement, Girdlestone resection arthroplasty, and arthrodesis and amputation are reported as possible treatments. Recently, two-stage revision has become popular as the gold standard treatment for chronic hip joint infections after THA. In this review, we evaluate the current literature about microbiology of periprosthetic joint infections and the use of antibiotic-loaded cement spacers. We aim to give an overview about indications, clinical results, and mechanical complications for spacers implantation, evaluating also selection criteria, pharmacokinetic properties, and systemic safety of the most frequently used antibiotics. PB - Georg Thieme Verlag KG DO - 10.1055/s-0039-1697608 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0039-1697608 ER -