TY - JOUR AU - Zheng, Danni; Nguyen, Quynh N.; Li, Rong; Dang, Vinh Q. TI - Is Intracytoplasmic Sperm Injection the Solution for all in Unexplained Infertility? SN - 1526-8004 SN - 1526-4564 PY - 2020 JO - Semin Reprod Med JF - Seminars in Reproductive Medicine LA - EN VL - 38 IS - 01 SP - 036 EP - 047 DA - 2020/11/05 KW - intracytoplasmic sperm injection KW - unexplained infertility KW - assisted reproductive technology KW - conventional in vitro fertilization KW - infertility AB - Intracytoplasmic sperm injection (ICSI) was first introduced as a supplemental method to conventional in vitro fertilization (c-IVF) for couples with severe male factor infertility to overcome the poor fertilization rate, while its indications expanded in current clinical practice and gained worldwide popularity. However, ICSI is invasive and crosses all natural barriers, raising several unresolved concerns regarding procedure-dependent and procedure-independent risks, as well as the characteristic of being labor-intensive and more expensive than c-IVF. This review is aimed to draw readers' attention, to the widespread use of ICSI worldwide, with its effectiveness in different indications of infertility, especially in those with unexplained infertility, as well as the cost-effectiveness of the ICSI-for-all strategy. Also, we covered current evidence on the short- and long-term safety of children born thanks to ICSI-aided conception. Further well-designed, adequately powered, and randomized controlled clinical trials are absolutely needed to arrive at a consensus on the use of ICSI over c-IVF in different populations. PB - Thieme Medical Publishers, Inc. DO - 10.1055/s-0040-1719085 UR - http://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0040-1719085 ER -